ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

Base Information

Chemical Name:ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate
CAS No.:1035155-79-3
Molecular Formula:C₂₀H₂₃ClO₆S
Molecular Weight:426.918
Hs Code.:

Synonyms:ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

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Chemical Property of ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

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Technology Process of ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

There total 7 articles about ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1035155-77-1
ethyl 3-{4-chloro-3-[(1S)-1,2-dihydroxyethyl]phenyl}propanoate

: 98-59-9
p-toluenesulfonyl chloride

: 1035155-79-3
ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

Guidance literature:: In pyridine; at 0 - 20 ℃;

Reference yield:

: 1035155-71-5
1-chloro-4-iodo-2-vinylbenzene

: 1035155-79-3
ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

1.2: 3 h / 20 °C

2.1: triethylamine / propiononitrile / 0.17 h

2.2: 16 h / 80 °C

3.1: hydrogen / Rh/Al₂O₃ / ethanol / 16 h / 20 °C

4.1: pyridine / 0 - 20 °C

With AD-mix-α; hydrogen; triethylamine; Rh/Al₂O₃; In pyridine; ethanol; water; propiononitrile; tert-butyl alcohol;

Reference yield:

: (2-chloro-5-iodophenyl)methan-1-ol

: 1035155-79-3
ethyl 3-[4-chloro-3-((1S)-1-hydroxy-2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: PCC / dichloromethane / 16.5 h / 20 °C

2.1: triphenylphosphine methyl bromide; potassium hexamethylsilazane / tetrahydrofuran; water / 1 h / -78 - 20 °C

3.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

3.2: 3 h / 20 °C

4.1: triethylamine / propiononitrile / 0.17 h

4.2: 16 h / 80 °C

5.1: hydrogen / Rh/Al₂O₃ / ethanol / 16 h / 20 °C

6.1: pyridine / 0 - 20 °C

With triphenylphosphine methyl bromide; AD-mix-α; hydrogen; potassium hexamethylsilazane; triethylamine; Rh/Al₂O₃; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; propiononitrile; tert-butyl alcohol;