3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one

Base Information

• Chemical Name: 3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one
• CAS No.: 1450829-42-1
• Molecular Formula: C₁₂H₁₂F₃NO₂
• Molecular Weight: 259.228
• Mol file: 1450829-42-1.mol

Synonyms:3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one

Chemical Property of 3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one

There total 2 articles about 3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-phenyl-2-(trifluoromethoxy)ethanone + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one (1450829-42-1)

Guidance literature:

In neat (no solvent); at 90 ℃; for 7h;

DOI:10.1016/j.jfluchem.2013.11.007

Reference yield:

iodoacetophenone (4636-16-2) → 3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one (1450829-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silver fluoride / acetonitrile / 2 h / -30 °C / Inert atmosphere; Sealed tube

1.2: 24.5 h / -30 - 20 °C / Inert atmosphere; Darkness

2.1: 5 h / Reflux

With silver fluoride; In acetonitrile;

Reference yield:

3-(dimethylamino)-1-phenyl-2-(trifluoromethoxy)prop-2-en-1-one (1450829-42-1) → 3-phenyl-4-(trifluoromethoxy)-1H-pyrazole (1450829-25-0)

Guidance literature:

With hydrazine hydrate; acetic acid; at 20 ℃;

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

iodoacetophenone

Downstream raw materials:

3-phenyl-4-(trifluoromethoxy)-1H-pyrazole