[(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Base Information

• Chemical Name: [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine
• CAS No.: 1114084-67-1
• Molecular Formula: C₁₆H₂₄BrNO₂
• Molecular Weight: 342.276
• Mol file: 1114084-67-1.mol

Synonyms:[(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Chemical Property of [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine

There total 4 articles about [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-(1,3-dioxolan-2-yl)-4-methylpentyl methanesulphonate (118214-76-9) + (S)-1-(4-bromophenyl)ethylamine (27298-97-1) → [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine (1114084-67-1)

Guidance literature:

With potassium carbonate; In acetonitrile; for 10h; Reflux;

Reference yield:

Methyl 4-methyl-3-oxopentanoate (42558-54-3) → [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine (1114084-67-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark trap

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 10 h

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

2-(2-isopropyl-1,3-dioxolan-2-yl)ethan-1-ol (113778-66-8) → [(S)-1-(4-bromo-phenyl)-ethyl]-[2-(2-isopropyl-[1,3]dioxolan-2-yl)-ethyl]-amine (1114084-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: potassium carbonate / acetonitrile / 10 h

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

upstream raw materials:

3-(1,3-dioxolan-2-yl)-4-methylpentyl methanesulphonate

(S)-1-(4-bromophenyl)ethylamine

Methyl 4-methyl-3-oxopentanoate

2-(2-isopropyl-1,3-dioxolan-2-yl)ethan-1-ol

Downstream raw materials:

1-[(S)-1-(4-bromo-phenyl)-ethylamino]-4-methyl-pentan-3-one