(S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

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Chemical Name:(S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester
CAS No.:138629-34-2
Molecular Formula:C₃₉H₄₄N₄O₇
Molecular Weight:680.801
Hs Code.:

Synonyms:(S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

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Chemical Property of (S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

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Technology Process of (S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

There total 14 articles about (S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 138629-34-2
(S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: LiBH₄

2: Et₃N, 4-dimethylaminopyridine

3: Et₃N, 4-dimethylaminopyridine

4: LiOOH, H₂O

5: 1.) t-BuCOCl, Et₃N, 2.) XpLi

6: trifluoroacetic acid

7: Et₃N

8: HF-pyridine / 13 h / 25 °C

9: DMSO, COCl₂, iPr₂NEt

10: MgSO₄ / CH₂Cl₂ / 1 h / 25 °C

11: PPh₃, C₂Cl₆, Et₃N / acetonitrile / 14 h / 35 °C

With dmap; lithium borohydride; lithium hydroperoxide; hexachloroethane; water; pivaloyl chloride; magnesium sulfate; pyridine hydrogenfluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/ja00030a063

Reference yield:

: (S)-4-[(R)-1-[(E)-Benzylimino-methyl]-4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butylcarbamoyl]-2-tert-butoxycarbonylamino-butyric acid benzyl ester

: 138629-34-2
(S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: With hexachloroethane; triethylamine; triphenylphosphine; In acetonitrile; at 35 ℃; for 14h; Yield given;
DOI:10.1021/ja00030a063

Reference yield:

: 6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
D-Glutamic acid

: 138629-34-2
(S)-4-{1-Benzyl-4-[3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-1H-imidazol-2-yl}-2-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 88 percent / SOCl₂, KOH / 150 °C

2: LiBH₄

3: Et₃N, 4-dimethylaminopyridine

4: Et₃N, 4-dimethylaminopyridine

5: LiOOH, H₂O

6: 1.) t-BuCOCl, Et₃N, 2.) XpLi

7: trifluoroacetic acid

8: Et₃N

9: HF-pyridine / 13 h / 25 °C

10: DMSO, COCl₂, iPr₂NEt

11: MgSO₄ / CH₂Cl₂ / 1 h / 25 °C

12: PPh₃, C₂Cl₆, Et₃N / acetonitrile / 14 h / 35 °C

With dmap; potassium hydroxide; lithium borohydride; thionyl chloride; lithium hydroperoxide; hexachloroethane; water; pivaloyl chloride; magnesium sulfate; pyridine hydrogenfluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/ja00030a063