N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide

Base Information

• Chemical Name: N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide
• CAS No.: 1035918-83-2
• Molecular Formula: C₂₀H₁₉IN₂O₄
• Molecular Weight: 478.286
• Mol file: 1035918-83-2.mol

Synonyms:N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide

Chemical Property of N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide

There total 1 articles about N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(4'-iodophenylamino)-N-methylphthalimide (1035918-76-3) + di-tert-butyl dicarbonate (24424-99-5) → N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide (1035918-83-2)

Guidance literature:

With dmap; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1002/ejoc.200800125

Reference yield: 47.0%

N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide (1035918-83-2) + 4-[2-[2,4-dimethyl-5-(pyridin-4-yl)thiophen-3-yl]-3,3,4,4,5,5-hexafluorocyclopent-1-enyl]-3,5-dimethylthiophene (1035918-86-5) → 4-[4-(4-{2-[2,4-dimethyl-5-(pyridin-4-yl)thiophen-3-yl]-3,3,4,4,5,5-hexafluorocyclopent-1-enyl}-3,5-dimethylthiophen-2-yl)-phenylamino]-N-(tert-butoxycarbonyl)-N-methylphthalimide (1035918-72-9)

Guidance literature:

4-[2-[2,4-dimethyl-5-(pyridin-4-yl)thiophen-3-yl]-3,3,4,4,5,5-hexafluorocyclopent-1-enyl]-3,5-dimethylthiophene; With 2,2,6,6-tetramethyl-piperidine; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; pentane; at -78 - 0 ℃;

N-butoxycarbonyl-4-(4'-iodophenylamino)-N-methylphthalimide; With triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; pentane; at 38 ℃; for 16h;

DOI:10.1002/ejoc.200800125

upstream raw materials:

4-(4'-iodophenylamino)-N-methylphthalimide

di-tert-butyl dicarbonate

Downstream raw materials:

4-[4-(4-{2-[2,4-dimethyl-5-(pyridin-4-yl)thiophen-3-yl]-3,3,4,4,5,5-hexafluorocyclopent-1-enyl}-3,5-dimethylthiophen-2-yl)-phenylamino]-N-(tert-butoxycarbonyl)-N-methylphthalimide