(E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate

Base Information

Chemical Name:(E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate
CAS No.:1258636-46-2
Molecular Formula:C₃₀H₃₃FO₃Si
Molecular Weight:488.674
Hs Code.:

Synonyms:(E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate

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Chemical Property of (E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate

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Technology Process of (E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate

There total 2 articles about (E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 352-34-1
4-fluoro-1-iodobenzene

: 1258636-22-4
[1-(2-bromophenyl)but-3-ynyloxy](tert-butyl)dimethylsilane

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1258636-46-2
(E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate

Guidance literature:: [1-(2-bromophenyl)but-3-ynyloxy](tert-butyl)dimethylsilane; With piperidine; copper(l) iodide; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

4-fluoro-1-iodobenzene; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

4-methoxycarbonylphenylboronic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 20h; Inert atmosphere;
DOI:10.1002/ejoc.201000515

Reference yield: 45.0%

: 1258636-22-4
[1-(2-bromophenyl)but-3-ynyloxy](tert-butyl)dimethylsilane

: 460-00-4
1-Bromo-4-fluorobenzene

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1258636-46-2
(E)-methyl 4-{[3-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-1-ylidene](4-fluorophenyl)methyl}benzoate

Guidance literature:: [1-(2-bromophenyl)but-3-ynyloxy](tert-butyl)dimethylsilane; With piperidine; copper(l) iodide; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

1-Bromo-4-fluorobenzene; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

4-methoxycarbonylphenylboronic acid; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 20h; Inert atmosphere;
DOI:10.1002/ejoc.201000515