4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether

Base Information

• Chemical Name: 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether
• CAS No.: 248601-84-5
• Molecular Formula: C₅₇H₉₂O₉Si
• Molecular Weight: 949.438

Synonyms:4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether

Chemical Property of 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether

There total 24 articles about 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-tert-butyldiphenylsilyl-13,22-bis(methoxymethyl)-8-dehydrosquamotacinyl trisether (248601-83-4) → 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether (248601-84-5)

Guidance literature:

With hydrogen; Wilkinson's catalyst; In ethanol; benzene; at 20 ℃; for 4h; under 760 Torr;

DOI:10.1021/jo990599p

Reference yield:

(4S,5S)-(-)-4,5-Dihydroxy-4,5-O-isopropylidenheptadecansaeure-methylester (142925-91-5) → 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether (248601-84-5)

Guidance literature:

Multi-step reaction with 24 steps

1.1: 97 percent / LiAlH₄ / diethyl ether / 0 °C / Heating

2.1: 84 percent / PCC; Celite / CH₂Cl₂ / 2 h / 20 °C

3.1: 88 percent / tetrahydrofuran; diethyl ether / 0.5 h / -20 °C

4.1: 86 percent / propionic acid / xylene / 2 h / Heating

5.1: 85 percent / TsOH / methanol; H₂O / 16 h / 20 °C

6.1: triethyl orthoacetate; chlorotrimethylsilane / CH₂Cl₂ / 0.5 h / 40 °C

6.2: 3.1 g / K₂CO₃ / methanol / 2 h / 20 °C

7.1: AD-mix-β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 16 h / 0 °C

7.2: 64 percent / Amberlyst 15 / CH₂Cl₂ / 16 h / 20 °C

8.1: 89 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

9.1: 90 percent / DIBAL-H / tetrahydrofuran; toluene / 1 h / -78 °C

10.1: 84 percent / toluene / 16 h / 80 °C

11.1: 98 percent / DIBAL-H / tetrahydrofuran; toluene / 1 h / -78 °C

12.1: (+)-diethyl tartrate; Ti(i-PrO)4; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / -20 °C

12.2: 82 percent / TBHP / CH₂Cl₂; 2,2,4-trimethyl-pentane / 16 h / -20 °C

13.1: 96 percent / DMAP; diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

14.1: 96 percent / triethylamine / CH₂Cl₂ / 2 h / -30 - 0 °C

15.1: 91 percent / TsOH / methanol / 2 h / 20 °C

16.1: 75 percent / K₂CO₃ / methanol / 1 h / 20 °C

17.1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C

17.2: 85 percent / BF₃*Et₂O / tetrahydrofuran / 1 h / -78 °C

18.1: 99 percent / H₂ / Lindlar catalyst / hexane / 2 h / 760 Torr

19.1: 87 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 0 - 20 °C

20.1: 95 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

21.1: 90 percent / I₂; PPh₃; imidazole / CH₂Cl₂ / 1 h / 0 °C

22.1: 87 percent / NaHCO₃ / acetonitrile / 48 h / 40 °C

23.1: n-BuLi / tetrahydrofuran / 0.33 h / 0 °C

23.2: 48 percent / tetrahydrofuran / 0.33 h / 0 °C

24.1: 96 percent / H₂ / Wilkinson's catalyst / ethanol; benzene / 4 h / 20 °C / 760 Torr

With 1H-imidazole; titanium(IV) isopropylate; dmap; lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; methanesulfonamide; 4 A molecular sieve; AD-mix-β; Celite; tetrabutyl ammonium fluoride; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; propionic acid; Triethyl orthoacetate; (+)-Weinsaeure-diethylester; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; pyridinium chlorochromate; Lindlar's catalyst; Wilkinson's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; toluene; acetonitrile; xylene; tert-butyl alcohol; benzene; 1.1: Reduction / 2.1: Oxidation / 3.1: Grignard reaction / 4.1: Condensation / 5.1: Substitution / 6.1: Substitution / 6.2: Cyclization / 7.1: Sharpless asymmetric dihydroxylation / 7.2: Cyclization / 8.1: Substitution / 9.1: Reduction / 10.1: Wittig-Horner reaction / 11.1: Reduction / 12.1: Sharpless asymmetric epoxidation / 12.2: Cyclization / 13.1: Substitution / 14.1: Substitution / 15.1: Substitution / 16.1: Cyclization / 17.1: Metallation / 17.2: Condensation / 18.1: Catalytic hydrogenatio;

DOI:10.1021/jo990599p

Reference yield:

(4R,5R,8R,9S) 5,8-oxidoheneicosa-9-hydroxy-1,4-olide (160708-85-0) → 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether (248601-84-5)

Guidance literature:

Multi-step reaction with 17 steps

1.1: 89 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

2.1: 90 percent / DIBAL-H / tetrahydrofuran; toluene / 1 h / -78 °C

3.1: 84 percent / toluene / 16 h / 80 °C

4.1: 98 percent / DIBAL-H / tetrahydrofuran; toluene / 1 h / -78 °C

5.1: (+)-diethyl tartrate; Ti(i-PrO)4; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / -20 °C

5.2: 82 percent / TBHP / CH₂Cl₂; 2,2,4-trimethyl-pentane / 16 h / -20 °C

6.1: 96 percent / DMAP; diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

7.1: 96 percent / triethylamine / CH₂Cl₂ / 2 h / -30 - 0 °C

8.1: 91 percent / TsOH / methanol / 2 h / 20 °C

9.1: 75 percent / K₂CO₃ / methanol / 1 h / 20 °C

10.1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C

10.2: 85 percent / BF₃*Et₂O / tetrahydrofuran / 1 h / -78 °C

11.1: 99 percent / H₂ / Lindlar catalyst / hexane / 2 h / 760 Torr

12.1: 87 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 0 - 20 °C

13.1: 95 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

14.1: 90 percent / I₂; PPh₃; imidazole / CH₂Cl₂ / 1 h / 0 °C

15.1: 87 percent / NaHCO₃ / acetonitrile / 48 h / 40 °C

16.1: n-BuLi / tetrahydrofuran / 0.33 h / 0 °C

16.2: 48 percent / tetrahydrofuran / 0.33 h / 0 °C

17.1: 96 percent / H₂ / Wilkinson's catalyst / ethanol; benzene / 4 h / 20 °C / 760 Torr

With 1H-imidazole; titanium(IV) isopropylate; dmap; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; (+)-Weinsaeure-diethylester; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; Lindlar's catalyst; Wilkinson's catalyst; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; toluene; acetonitrile; benzene; 1.1: Substitution / 2.1: Reduction / 3.1: Wittig-Horner reaction / 4.1: Reduction / 5.1: Sharpless asymmetric epoxidation / 5.2: Cyclization / 6.1: Substitution / 7.1: Substitution / 8.1: Substitution / 9.1: Cyclization / 10.1: Metallation / 10.2: Condensation / 11.1: Catalytic hydrogenation / 12.1: Substitution / 13.1: Substitution / 14.1: Substitution / 15.1: Addition / 16.1: Metallation / 16.2: Wittig reaction / 17.1: Catalytic hydrogenation;

DOI:10.1021/jo990599p

upstream raw materials:

4-tert-butyldiphenylsilyl-13,22-bis(methoxymethyl)-8-dehydrosquamotacinyl trisether

(4S,5S)-(-)-4,5-Dihydroxy-4,5-O-isopropylidenheptadecansaeure-methylester

(4R,5R,8R,9S) 5,8-oxidoheneicosa-9-hydroxy-1,4-olide

3-((4S,5S)-5-Dodecyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 248601-84-5 4-tert-butyldiphenylsilyl-14,23-bis(methoxymethyl)squamotacinyl trisether

Send

Send

Metric Ton KG G Pound L ML

Send

Send