Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

Base Information

Chemical Name:Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole
CAS No.:1279106-60-3
Molecular Formula:C₃₁H₂₃F₂N₃O₂S
Molecular Weight:539.605
Hs Code.:

Synonyms:Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

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Chemical Property of Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

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Technology Process of Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

There total 8 articles about Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1279105-72-4
trifluoro-methanesulfonic acid 2-ethyl-5-phenyl-2H-pyrazol-3-yl ester

: 1279107-81-1
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole

: 1279106-60-3
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 10h; Inert atmosphere;

Reference yield:

: 1279105-71-3
2-Ethyl-5-phenyl-2H-pyrazol-3-ol

: 1279106-60-3
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / -78 - 25 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 10 h / 100 °C / Inert atmosphere

With potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279106-60-3
Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(2-ethyl-5-phenyl-2H-pyrazol-3-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 25 °C

2.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 10 h / 100 °C / Inert atmosphere

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;