Technology Process of 1-phenyl-2-propyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrole
There total 8 articles about 1-phenyl-2-propyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dodecacarbonyl-triangulo-triruthenium;
In
toluene;
at 100 ℃;
for 10h;
chemoselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201405215
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydride / tetrahydrofuran
2: pyridinium chlorochromate / dichloromethane / 20 °C
3: potassium carbonate / methanol / 20 °C
4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 10 h / 20 °C / Inert atmosphere
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
6: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
7: magnesium sulfate / dichloromethane / 50 °C / Sealed tube; Inert atmosphere
8: dodecacarbonyl-triangulo-triruthenium / toluene / 10 h / 100 °C / Inert atmosphere; Schlenk technique
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dodecacarbonyl-triangulo-triruthenium; tetrabutyl ammonium fluoride; sodium hydride; magnesium sulfate; potassium carbonate; triethylamine; pyridinium chlorochromate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1002/anie.201405215
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridinium chlorochromate / dichloromethane / 20 °C
2: potassium carbonate / methanol / 20 °C
3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 10 h / 20 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
6: magnesium sulfate / dichloromethane / 50 °C / Sealed tube; Inert atmosphere
7: dodecacarbonyl-triangulo-triruthenium / toluene / 10 h / 100 °C / Inert atmosphere; Schlenk technique
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dodecacarbonyl-triangulo-triruthenium; tetrabutyl ammonium fluoride; magnesium sulfate; potassium carbonate; triethylamine; pyridinium chlorochromate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1002/anie.201405215
