dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

Base Information

Chemical Name:dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate
CAS No.:797034-75-4
Molecular Formula:C₁₅H₂₄NO₆PS
Molecular Weight:377.398
Hs Code.:

Synonyms:dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

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Chemical Property of dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

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Technology Process of dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

There total 3 articles about dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 51220-85-0,21957-66-4
Methyl (S)-N-<(4-methylphenyl)sulfonyl>valinate

: 756-79-6
dimethyl methane phosphonate

: 797034-75-4
dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 1.5h;

Methyl (S)-N-<(4-methylphenyl)sulfonyl>valinate; In tetrahydrofuran; hexane; at -78 ℃; for 4h;
DOI:10.1016/j.tetasy.2004.08.012

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 797034-75-4
dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -50 °C

2.2: 98 percent / tetrahydrofuran; hexane / 4 h / -78 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2004.08.012

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 797034-75-4
dimethyl (S)-3-[(p-toluenesulfonyl)amino]-4-methyl-2-oxopentylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -50 °C

2.2: 98 percent / tetrahydrofuran; hexane / 4 h / -78 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2004.08.012