5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester

Base Information

• Chemical Name: 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester
• CAS No.: 462656-34-4
• Molecular Formula: C₂₀H₂₃ClN₂O₃
• Molecular Weight: 374.867
• Mol file: 462656-34-4.mol

Synonyms:5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester

Chemical Property of 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester

There total 8 articles about 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E/Z)-5-[[[3-(hydroxymethyl)-phenyl-3-pyridyl]methylene]aminooxy]pentanoic acid ethyl ester (218153-08-3) → 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester (462656-34-4)

Guidance literature:

With thionyl chloride; In dichloromethane;

DOI:10.1016/S0960-894X(01)00731-4

Reference yield:

5-[1-(3-Methanesulfonyloxymethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester (218153-06-1) → 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester (462656-34-4)

Guidance literature:

With sodium chloride; In chloroform;

DOI:10.1016/S0960-894X(02)00005-7

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → 5-[1-(3-Chloromethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester (462656-34-4)

Guidance literature:

Multi-step reaction with 6 steps

1: n-BuLi / tetrahydrofuran / -78 °C

2: MnO₂ / CH₂Cl₂ / 50 °C

3: NH₂OH*HCl; Py / ethanol / Heating

4: NaH / dimethylformamide

5: 100 percent / TBAF / tetrahydrofuran

6: SOCl₂ / CH₂Cl₂

With pyridine; manganese(IV) oxide; n-butyllithium; thionyl chloride; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00731-4

upstream raw materials:

(E/Z)-5-[[[3-(hydroxymethyl)-phenyl-3-pyridyl]methylene]aminooxy]pentanoic acid ethyl ester

5-[1-(3-Methanesulfonyloxymethyl-phenyl)-1-pyridin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid ethyl ester

3-pyridinecarboxaldehyde

3-bromo-O-(tert-butyldiphenylsilyl)benzyl ether