(RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:(RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1392105-65-5
Molecular Formula:C₁₇H₁₆F₂N₂O
Molecular Weight:302.324
Hs Code.:

Synonyms:(RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Chemical Property of (RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of (RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 6 articles about (RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1262858-69-4
rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

: 144025-03-6
2,4-difluorophenylboronic acid

: 1392105-65-5
(RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 100 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield:

: 1262858-66-1
rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide

: 1392105-65-5
(RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tert-Amyl alcohol / 1 h / 20 - 30 °C

2: dichloromethane / 17 h / 20 °C / Inert atmosphere

3: ammonium chloride / methanol / 100 °C / Sealed tube

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 100 °C / Inert atmosphere; Sealed tube

With potassium tert-butylate; sodium hydrogencarbonate; ammonium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; tert-Amyl alcohol; dichloromethane;

Reference yield:

: 1262858-67-2
rac-5-(3-bromophenyl)-5-methylmorpholin-3-one

: 1392105-65-5
(RS)-5-(2',4'-difluoro-biphenyl-3-yl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 17 h / 20 °C / Inert atmosphere

2: ammonium chloride / methanol / 100 °C / Sealed tube

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 100 °C / Inert atmosphere; Sealed tube

With sodium hydrogencarbonate; ammonium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane;