(3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine

Base Information

• Chemical Name: (3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine
• CAS No.: 1433607-35-2
• Molecular Formula: C₃₀H₃₅FN₆O₃
• Molecular Weight: 546.645
• Mol file: 1433607-35-2.mol

Synonyms:(3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine

Chemical Property of (3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine

There total 2 articles about (3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl (3S)-3-(bromomethyl)pyrrolidine-1-carboxylate (1067230-64-1) + (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime (1433605-21-0) → (3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine (1433607-35-2)

Guidance literature:

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.0833333h; Inert atmosphere;

tert-butyl (3S)-3-(bromomethyl)pyrrolidine-1-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 80 ℃;

Reference yield:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate (199174-24-8) → (3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine (1433607-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

2.2: 80 °C

With carbon tetrabromide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield: 65.0%

(3S)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)methyl)pyrrolidine (1433607-35-2) → (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(S)-1-(pyrrolidin-3-yl)methyl oxime trihydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl (3S)-3-(bromomethyl)pyrrolidine-1-carboxylate

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime