Technology Process of SR6781
There total 4 articles about SR6781 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C17H17F3N4O;
With
water; lithium hydroxide;
In
1,4-dioxane;
at 100 ℃;
Inert atmosphere;
With
hydrogenchloride;
In
1,4-dioxane; water;
3-METHOXYBENZYLAMINE;
With
triethylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate / 1,4-dioxane; water / 110 °C
2: sodium hydroxide / 14 h / Reflux
3: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C
With
trans-bis(triphenylphosphine)palladium dichloride; sodium carbonate; triethylamine; HATU; sodium hydroxide;
In
1,4-dioxane; water; N,N-dimethyl-formamide;
1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.09.084
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / 14 h / Reflux
2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C
With
triethylamine; HATU; sodium hydroxide;
In
N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.084