benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid

Base Information

• Chemical Name: benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid
• CAS No.: 851916-02-4
• Molecular Formula: C₈H₁₆N₂O₁₂P₄
• Molecular Weight: 456.116
• Mol file: 851916-02-4.mol

Synonyms:benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid

Chemical Property of benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid

There total 5 articles about benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

octaethyl benzene-1,4-bis[aminomethylidene(bisphosphonate)] (1620164-64-8) → benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid (851916-02-4)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2014.05.071

Reference yield:

1,4-phenylenediamine (106-50-3) → benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid (851916-02-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene / 8 h / Reflux

2.1: triethylamine / dichloromethane / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / -15 °C

4.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With hydrogenchloride; trimethylsilyl bromide; triethylamine; In 1,4-dioxane; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2014.05.071

Reference yield:

1,4-phenylenediisocyanide (935-16-0) → benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid (851916-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / -15 °C

2: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With hydrogenchloride; trimethylsilyl bromide; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2014.05.071

upstream raw materials:

octaethyl benzene-1,4-bis[aminomethylidene(bisphosphonate)]

1,4-phenylenediamine

N-(4-formylaminophenyl)formamide

1,4-phenylenediisocyanide