5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole
CAS No.:1334718-88-5
Molecular Formula:C₁₉H₁₄ClF₃N₄O₂
Molecular Weight:422.794
Hs Code.:

Synonyms:5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

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Chemical Property of 5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

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Technology Process of 5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

There total 3 articles about 5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1216142-18-5
6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylic acid

: 280110-83-0
C₉H₉F₃N₂O₂

: 1334718-88-5
5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

Guidance literature:: 6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

C₉H₉F₃N₂O₂; In N,N-dimethyl-formamide; at 140 ℃; for 2h;

Reference yield:

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1334718-88-5
5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 1 h / 20 °C

2.1: water; hydroxylamine / ethanol / Reflux

3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 2 h / 140 °C

With water; hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 49561-96-8
(4-trifluoromethoxy-phenyl)-acetonitrile

: 1334718-88-5
5-(6-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; hydroxylamine / ethanol / Reflux

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h / 140 °C

With water; hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;