(S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

Base Information

Chemical Name:(S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine
CAS No.:1443751-93-6
Molecular Formula:C₁₄H₁₅F₆NOS
Molecular Weight:359.336
Hs Code.:

Synonyms:(S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

Chemical Property:

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Technology Process of (S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

There total 2 articles about (S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₃F₆NOS

: 1774-47-6
trimethylsulfoxonium iodide

: 1443751-93-6
(S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

: 1443751-87-8
(R)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

C₁₃H₁₃F₆NOS; In N,N-dimethyl-formamide; at -45 ℃; for 1.5h; Overall yield = 61 %; diastereoselective reaction;
DOI:10.1016/j.tetlet.2013.05.048

Reference yield:

: 74853-66-0
4'-trifluoromethyl-2,2,2-trifluoroacetophenone

: 1443751-93-6
(S)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

: 1443751-87-8
(R)-1-((S)-tert-butylsulfinyl)-2-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / hexane / 0.17 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 1.5 h / -45 °C

With titanium(IV) isopropylate; sodium hydride; In hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2013.05.048