N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide

Base Information

• Chemical Name: N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide
• CAS No.: 1295561-41-9
• Molecular Formula: C₁₈H₁₉NO₂S
• Molecular Weight: 313.42
• Mol file: 1295561-41-9.mol

Synonyms:N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property of N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide

There total 3 articles about N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

iodobenzene (591-50-4) + N-ethynyl-4-methyl-N-(1-methylethyl)-benzenesulfonamide → N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide (1295561-41-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cetyltrimethylammonim bromide; caesium carbonate; In water; at 60 ℃; for 10h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1021/acs.joc.0c02326

Reference yield: 76.0%

N-isopropyl-p-toluenesulfonamide (21230-07-9) + 1-Bromo-2-phenylacetylene (932-87-6) → N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide (1295561-41-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In toluene; at 60 ℃; for 20h;

DOI:10.1021/ol200812y

Reference yield:

phenylacetylene (536-74-3) → N-isopropyl-4-methyl-N-(phenylethynyl)benzenesulfonamide (1295561-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: silver nitrate; N-Bromosuccinimide / acetone / 3 h / 20 °C / Inert atmosphere

2: potassium carbonate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 80 °C / Inert atmosphere

With N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; silver nitrate; In acetone; toluene;

DOI:10.1002/adsc.201800341

upstream raw materials:

N-isopropyl-p-toluenesulfonamide

1-Bromo-2-phenylacetylene

phenylacetylene

iodobenzene