9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Base Information

Chemical Name:9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid
CAS No.:1549948-01-7
Molecular Formula:C₂₇H₃₁ClF₃NO₃
Molecular Weight:509.996
Hs Code.:

Synonyms:9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

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Chemical Property of 9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

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Technology Process of 9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

There total 8 articles about 9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1549953-37-8
C₂₈H₃₃ClF₃NO₃

: 1549948-01-7
9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 1h;

Reference yield:

: 75091-92-8,75091-93-9,30129-18-1
4-(trifluoromethyl)cyclohexan-1-ol

: 1549948-01-7
9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 85 °C

3: ISCO column chromatography / Resolution of racemate

4: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

5: N-chloro-succinimide / acetonitrile / 0.33 h / 80 °C / Microwave irradiation

6: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

With N-chloro-succinimide; water; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1266120-65-3
4-(trifluoromethyl)cyclohexyl methanesulfonate

: 1549948-01-7
9-((5-chloro-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

2: ISCO column chromatography / Resolution of racemate

3: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

4: N-chloro-succinimide / acetonitrile / 0.33 h / 80 °C / Microwave irradiation

5: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

With N-chloro-succinimide; water; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;