4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde

Base Information

• Chemical Name: 4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde
• CAS No.: 1376708-06-3
• Molecular Formula: C₁₄H₁₆FNO
• Molecular Weight: 233.286
• Mol file: 1376708-06-3.mol

Synonyms:4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde

Chemical Property of 4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde

There total 2 articles about 4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

potassium 3-(pyrrolidin-1-yl)prop-1-en-2-yltrifluoroborate + 4-bromo-2-fluorobenzaldehyde (57848-46-1) → 4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde (1376708-06-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In water; toluene; for 16h; regiospecific reaction; Reflux;

DOI:10.1016/j.tetlet.2012.03.119

Reference yield:

1-(2-bromo-allyl)-pyrrolidine (36138-67-7) → 4-[3-(pyrrolidin-1-yl)prop-1-en-2-yl]-2-fluorobenzaldehyde (1376708-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -75 °C

1.2: -75 - 20 °C

1.3: 5 h / 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; toluene / 16 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; caesium carbonate; In diethyl ether; water; toluene; pentane; 2.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2012.03.119

upstream raw materials:

1-(2-bromo-allyl)-pyrrolidine

4-bromo-2-fluorobenzaldehyde