5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Base Information

Chemical Name:5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide
CAS No.:625457-65-0
Molecular Formula:C₄₀H₄₅N₃O₄S₂
Molecular Weight:695.947
Hs Code.:

Synonyms:5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Suppliers and Price of 5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

There total 5 articles about 5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 625457-63-8
5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentanoic acid chrysen-6-ylamide

: 625457-65-0
5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Guidance literature:: With tin(ll) chloride; In ethyl acetate; for 3h; Heating;
DOI:10.1016/S0960-894X(03)00743-1

Reference yield:

: 127810-77-9
(2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal

: 625457-65-0
5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

2: K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: aq. LiOH / tetrahydrofuran; methanol / 12 h / 20 °C

4: isobutyl chloroformate; triethylamine / 12 h / 20 °C

5: 72 percent / SnCl₂*2H₂O / ethyl acetate / 3 h / Heating

With lithium hydroxide; boron trifluoride diethyl etherate; potassium carbonate; triethylamine; ethanethiol; tin(ll) chloride; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00743-1

Reference yield:

: 140647-02-5
(2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 625457-65-0
5-{5-Amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentanoic acid chrysen-6-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 24 h / 20 °C

2: aq. LiOH / tetrahydrofuran; methanol / 12 h / 20 °C

3: isobutyl chloroformate; triethylamine / 12 h / 20 °C

4: 72 percent / SnCl₂*2H₂O / ethyl acetate / 3 h / Heating

With lithium hydroxide; potassium carbonate; triethylamine; tin(ll) chloride; isobutyl chloroformate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00743-1