(1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

Base Information

Chemical Name:(1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde
CAS No.:1288984-91-7
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:(1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

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Chemical Property of (1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

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Technology Process of (1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

There total 3 articles about (1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1963-36-6
4-methoxycinnamaldehyde

: 4591-64-4,51262-17-0,51262-18-1,84025-84-3,84025-87-6,84025-83-2,1212469-34-5
(S)-2-[(R)-2-nitro-1-phenylethyl]cyclohexanone

: 8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

: 1288984-91-7
(1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

Guidance literature:: 4-methoxycinnamaldehyde; With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid; In toluene; at 20 ℃; for 0.5h;

(S)-2-[(R)-2-nitro-1-phenylethyl]cyclohexanone; With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 24h; optical yield given as %ee; stereoselective reaction;
DOI:10.1021/ol200424x

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

: 1288984-91-7
(1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: C₁₄H₂₆N₂O / neat (no solvent)

2.1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid / toluene / 0.5 h / 20 °C

2.2: 24 h / 20 °C

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; C₁₄H₂₆N₂O; acetic acid; In toluene; 1.1: Michael addition reaction;
DOI:10.1021/ol200424x

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

: 1288984-91-7
(1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-2-(4-methoxyphenyl)-3-nitro-4-phenyldecahydronaphthalene-1-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: C₁₄H₂₆N₂O / neat (no solvent)

2.1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid / toluene / 0.5 h / 20 °C

2.2: 24 h / 20 °C

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; C₁₄H₂₆N₂O; acetic acid; In toluene; 1.1: Michael addition reaction;
DOI:10.1021/ol200424x