(2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate

Base Information

• Chemical Name: (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate
• CAS No.: 409113-02-6
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 409113-02-6.mol

Synonyms:(2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate

Chemical Property of (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate

There total 12 articles about (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl (E)-2-(p-methoxyphenylimino)acetate (115276-75-0,124156-21-4,120419-96-7) + butanone (78-93-3) → (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate (409113-02-6)

Guidance literature:

N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide; In dimethyl sulfoxide; at 20 ℃; for 11h; Product distribution / selectivity;

Reference yield: 84.0%

ethyl (E)-2-(p-methoxyphenylimino)acetate (115276-75-0,124156-21-4,120419-96-7) + butanone (78-93-3) → ethyl 2-(4-methoxyphenylamino)-3-methyl-4-oxo-pentanoate + (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate (409113-02-6)

Guidance literature:

(S)-2-(trifluoromethane-sulfonylamino-methyl)-pyrrolidine; In dimethyl sulfoxide; at 20 ℃; for 11h;

DOI:10.1016/j.tetlet.2004.08.032

Reference yield: 77.0%

ethyl (4-methoxyphenylimino)acetate (124156-21-4) + butanone (78-93-3) → (2S,3S)-ethyl 2-(p-methoxyphenylamino)-3-methyl-4-oxo-pentanoate (409113-02-6)

Guidance literature:

With (2S)-N-(2-pyrrolidine-2-carbonyl)-methanesulfonamide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1039/b414742a

upstream raw materials:

ethyl (E)-2-(p-methoxyphenylimino)acetate

butanone

ethyl (4-methoxyphenylimino)acetate

glyoxylic acid ethyl ester

Downstream raw materials:

(3S,4R,5S)-3-amino-4,5-dimethyldihydrofuran-2(3H)-one

(3S,4R,5R)-3-Amino-4,5-dimethyl-dihydro-furan-2-one

C₆H₁₁NO₂

(3S,4S,5R)-3-amino-4,5-dimethyldihydrofuran-2(3H)-one