(S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Base Information

Chemical Name:(S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide
CAS No.:139072-23-4
Molecular Formula:C₁₉H₂₂F₃N₃O₄Si
Molecular Weight:441.482
Hs Code.:

Synonyms:(S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

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Chemical Property of (S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

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Technology Process of (S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

There total 4 articles about (S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 139072-01-8
(S)-N-<<3-<4-iodo-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

: 1066-54-2
trimethylsilylacetylene

: 139072-23-4
(S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; for 2.5h; Ambient temperature;
DOI:10.1021/jm00084a022

Reference yield:

: 139071-78-6
N-[(S)-3-(3-Nitro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

: 139072-23-4
(S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / PtO₂ / aq. ethanol / 2327.2 Torr

2: Et₃N / tetrahydrofuran / 5 - 10 °C

3: 100 percent / I₂, silver trifluoroacetate / acetonitrile / 27 h

4: 66 percent / bis(triphenylphosphine) palladium(II) chloride, copper(I) iodide, Et₃N / dimethylformamide / 2.5 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; iodine; silver trifluoroacetate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00084a022

Reference yield:

: 139071-83-3
N-[(S)-3-(3-Amino-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

: 139072-23-4
(S)-N-<<3-<4-<(trimethylsilyl)ethynyl>-3-(trifluoroacetamido)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 5 - 10 °C

2: 100 percent / I₂, silver trifluoroacetate / acetonitrile / 27 h

3: 66 percent / bis(triphenylphosphine) palladium(II) chloride, copper(I) iodide, Et₃N / dimethylformamide / 2.5 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; silver trifluoroacetate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00084a022