tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

Base Information

Chemical Name:tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate
CAS No.:951659-67-9
Molecular Formula:C₂₂H₂₄INO₆
Molecular Weight:525.34
Hs Code.:

Synonyms:tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

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Chemical Property of tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

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Technology Process of tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

There total 4 articles about tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 951659-65-7
3-tert-butoxycarbonylmethoxy-4-iodo-benzoic acid

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: 951659-67-9
tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1039/b708449h

Reference yield:

: 951659-66-8
tert-butyl (5-formyl-2-iodo-phenoxy)-acetate

: 951659-67-9
tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NaClO₂; NaH₂PO₄; aq. H₂O₂ / acetonitrile / 2 h / 20 °C

2: 100 percent / i-Pr₂NEt; HATU / dimethylformamide / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b708449h

Reference yield:

: 135242-71-6
3-hydroxy-4-iodobenzaldehyde

: 951659-67-9
tert-butyl [5-(benzyloxycarbonylmethyl-carbamoyl)-2-iodo-phenoxy]-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / cesium carbonate / dimethylformamide / 0.25 h / 90 °C

2: 91 percent / NaClO₂; NaH₂PO₄; aq. H₂O₂ / acetonitrile / 2 h / 20 °C

3: 100 percent / i-Pr₂NEt; HATU / dimethylformamide / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b708449h