sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate

Base Information

• Chemical Name: sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate
• CAS No.: 1444512-87-1
• Molecular Formula: C₉H₁₀FNO₄P*Na
• Molecular Weight: 269.145
• Mol file: 1444512-87-1.mol

Synonyms:sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate

Chemical Property of sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate

There total 5 articles about sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

[N-(3-fluorophenyl)carbamoyl]ethylphosphonic acid (1444512-38-2) → sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate (1444512-87-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2013.04.076

Reference yield:

C15H27FNO4PSi2 → sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate (1444512-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; water / 0.5 h / 20 °C

2: sodium hydroxide / ethanol / 0.5 h / 20 °C

With methanol; water; sodium hydroxide; In ethanol;

DOI:10.1016/j.bmc.2013.04.076

Reference yield:

3-chloro-N-(3-fluoro-phenyl)-propionamide (100638-26-4) → sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate (1444512-87-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 9 h / Inert atmosphere; Reflux

2: acetonitrile / 0.17 h / 60 - 100 °C / Microwave irradiation

3: methanol; water / 0.5 h / 20 °C

4: sodium hydroxide / ethanol / 0.5 h / 20 °C

With methanol; water; sodium hydroxide; In ethanol; acetonitrile; 1: |Michaelis-Arbuzov Synthesis;

DOI:10.1016/j.bmc.2013.04.076

upstream raw materials:

[N-(3-fluorophenyl)carbamoyl]ethylphosphonic acid

3-chloro-N-(3-fluoro-phenyl)-propionamide

diethyl [N-(3-fluorophenyl)carbamoyl]ethylphosphonate

meta-fluoroaniline

Refernces