(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

Base Information

Chemical Name:(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester
CAS No.:802911-34-8
Molecular Formula:C₂₃H₃₄N₂O₃
Molecular Weight:386.535
Hs Code.:

Synonyms:(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

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Chemical Property of (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

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Technology Process of (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

There total 10 articles about (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 802911-33-7
(2S,3S)-2-((2S,3R)-2-Benzyloxycarbonylamino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

: 802911-34-8
(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; ambient pressure;
DOI:10.1002/chem.200400249

Reference yield:

: 802911-18-8
(2S,3S)-2-Amino-3-methyl-pentanoic acid dicyclopropylmethyl ester

: 802911-34-8
(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 0.50 g / TMP / CH₂Cl₂ / 6 h / 20 °C

2.1: H₂ / Pd/C / ethyl acetate / 2 h / ambient pressure

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1002/chem.200400249

Reference yield:

: 321524-72-5
N-Z-3-(2S,3R)-β-methylphenylalanine

: 802911-34-8
(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 0.50 g / TMP / CH₂Cl₂ / 6 h / 20 °C

2.1: H₂ / Pd/C / ethyl acetate / 2 h / ambient pressure

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1002/chem.200400249