6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

Base Information

Chemical Name:6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine
CAS No.:1421044-96-3
Molecular Formula:C₂₅H₃₁N₅O
Molecular Weight:417.554
Hs Code.:

6-(mesityloxy)-N<SUP>2</SUP>-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

Synonyms:6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

Suppliers and Price of 6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

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Technology Process of 6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

There total 6 articles about 6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1421045-20-6
6-(mesityloxy)-N²-(piperidin-4-yl)pyridine-2,3-diamine

: 1822-51-1
4-picolylchloride hydrochloride

: 1421044-96-3
6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

Guidance literature:: With potassium carbonate; In acetone; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300130

Reference yield:

: 1421045-18-2
6-(mesityloxy)-N²-(1-Boc-piperidin-4-yl)pyridine-2,3-diamine

: 1421044-96-3
6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / acetone / 0 - 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1002/cmdc.201300130

Reference yield:

: 400801-28-7
(6-chloro-3-nitropyridin-2-yl)-(1-Boc-piperidin-4-yl)amine

: 1421044-96-3
6-(mesityloxy)-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,3-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 1,4-dioxane / 0.25 h / 20 °C

1.2: 7 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: potassium carbonate / acetone / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; acetone;
DOI:10.1002/cmdc.201300130