O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime

Base Information

• Chemical Name: O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime
• CAS No.: 81638-97-3
• Molecular Formula: C₃₁H₂₉N₃O₅
• Molecular Weight: 523.588
• Mol file: 81638-97-3.mol

Synonyms:O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime

Chemical Property of O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime

There total 1 articles about O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-pyridin-2-yl-ethanone oxime (1758-54-9,79462-42-3,81563-77-1) + N-benzyloxycarbonyl-O-benzyl-L-tyrosine (86827-18-1,92455-53-3,16677-29-5) → O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime (81638-97-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; Ambient temperature;

Reference yield:

O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime (81638-97-3) → Leu-enkephalin (58822-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NH₃, 2.) AcOH / 1.) CHCl₃, 5 min, 2.) THF, 20 h

2: 60 percent / H₂ / 5percent Pd/C / methanol; H₂O / 24 h / 760 Torr

With ammonia; hydrogen; acetic acid; palladium on activated charcoal; In methanol; water;

Reference yield:

hydrochloride of 4-nitrobenzyl ester of glycyl-glycyl-L-phenylalanyl-L-leucine (81649-51-6) + O-(N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-2-pyridylmethylketoxime (81638-97-3) → 4-nitrobenzyl ester of N-benzyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine (75244-08-5)

Guidance literature:

With ammonia; acetic acid; Yield given. Multistep reaction; 1.) CHCl₃, 5 min, 2.) THF, 20 h;

upstream raw materials:

1-pyridin-2-yl-ethanone oxime

N-benzyloxycarbonyl-O-benzyl-L-tyrosine

Downstream raw materials:

4-nitrobenzyl ester of N-benzyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Leu-enkephalin