N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

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Chemical Name:N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide
CAS No.:91377-22-9
Molecular Formula:C₃₈H₆₄F₃N₃O₉S
Molecular Weight:796.002
Hs Code.:

N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

Synonyms:N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

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Chemical Property of N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

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Technology Process of N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

There total 13 articles about N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: N-(4-Amino-butyl)-N-{3-[(2S,6R)-6-((1R,2S)-1,2-bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-4-methyl-benzenesulfonamide

: 407-25-0
trifluoroacetic anhydride

: 91377-22-9
N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4039(01)80076-9

Reference yield:

: 61341-03-5
N-(toluene-4-sulfonyl)-β-alanyl chloride

: 91377-22-9
N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / K₂CO₃ / benzene; toluene; H₂O / 0 - 10 °C

2: 85 percent / LiAlH₄ / tetrahydrofuran / Heating

3: 96 percent / K₂CO₃ / dimethylformamide / Ambient temperature

4: 80percent aq. NH₂NH₂ / ethanol / Ambient temperature

5: 70 percent / Et₃N / CH₂Cl₂ / -78 °C

With lithium aluminium tetrahydride; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(01)80076-9

Reference yield:

: (2R,6S)-6-((1S,2R)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-1,2,3,6-tetrahydro-pyridine

: 91377-22-9
N-{4-[{3-[(2S,6R)-6-((1R,2S)-1,2-Bis-methoxymethoxy-heptyl)-2-(2,2-diethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-(toluene-4-sulfonyl)-amino]-butyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / K₂CO₃ / benzene; toluene; H₂O / 0 - 10 °C

2: 85 percent / LiAlH₄ / tetrahydrofuran / Heating

3: 96 percent / K₂CO₃ / dimethylformamide / Ambient temperature

4: 80percent aq. NH₂NH₂ / ethanol / Ambient temperature

5: 70 percent / Et₃N / CH₂Cl₂ / -78 °C

With lithium aluminium tetrahydride; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(01)80076-9