(S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine

Base Information

• Chemical Name: (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine
• CAS No.: 444904-02-3
• Molecular Formula: C₁₆H₂₃NO
• Molecular Weight: 245.365

Synonyms:(S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine

Chemical Property of (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine

Chemical Property:

Purity/Quality:

More than 98% ^*data from raw suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine

There total 7 articles about (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbonic acid, ethyl (3SR,4RS)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester (149541-62-8) → (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine (444904-02-3) + (R)-1,2,3,4-tetrahydro-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>pyridine (143919-32-8)

Guidance literature:

In decalin; at 190 - 195 ℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo951403y

Reference yield:

1,3-dimethyl-4-piperidinone (4629-80-5) → (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine (444904-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran

2.1: ethyl acetate

2.2: (+)-diethyl ditoluyltartrate

3.1: decahydronaphthalene / Heating

In tetrahydrofuran; ethyl acetate; decalin;

DOI:10.1021/jm030094y

Reference yield:

Carbonic acid ethyl ester (3R,4S)-4-(3-isopropoxy-phenyl)-1,3-dimethyl-piperidin-4-yl ester (149541-62-8) → (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine (444904-02-3)

Guidance literature:

In decalin; Heating;

DOI:10.1021/jm030094y

upstream raw materials:

carbonic acid, ethyl (3SR,4RS)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester

Carbonic acid ethyl ester (3R,4S)-4-(3-isopropoxy-phenyl)-1,3-dimethyl-piperidin-4-yl ester

1,3-dimethyl-4-piperidinone

C₁₉H₂₉NO₄

Downstream raw materials:

(-)-(1R,4S,5S)-5-[3-(1-methylethoxy)phenyl]-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-one

(3S,4S)-4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine

2‐((S)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid

2‐((R)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid

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