Technology Process of (4S,5R)-3-((2R,3R)-2,3-dimethyl-hexanoyl)-4,5-diphenyl-oxazolidin-2-one
There total 5 articles about (4S,5R)-3-((2R,3R)-2,3-dimethyl-hexanoyl)-4,5-diphenyl-oxazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methylmagnesium chloride;
With
copper(I) bromide (methylsulfanyl)methane complex; lithium chloride;
In
tetrahydrofuran;
at -35 ℃;
Inert atmosphere;
(4S,5R)-3-((E)-2-methyl-hex-2-enoyl)-4,5-diphenyl-oxazolidin-2-one;
In
tetrahydrofuran;
at -30 ℃;
for 4h;
Inert atmosphere;
With
acetic acid;
In
tetrahydrofuran;
at 0 ℃;
stereoselective reaction;
DOI:10.1016/j.tetlet.2008.12.111
- Guidance literature:
-
methylmagnesium chloride;
With
copper(I) bromide dimethylsulfide complex; lithium chloride;
In
tetrahydrofuran;
at -35 - 20 ℃;
for 1.25h;
(4S,5R)-3-((E)-2-methyl-hex-2-enoyl)-4,5-diphenyl-oxazolidin-2-one;
In
tetrahydrofuran; acetic acid;
at -30 - 0 ℃;
for 6.5h;
With
ammonia; ammonium chloride;
In
tetrahydrofuran; water; acetic acid;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium ethanolate / ethanol; toluene / 7 h / 90 - 110 °C / Heating / reflux
2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C
2.2: 2 h / 0 - 20 °C
3.1: copper(I) bromide dimethylsulfide complex; lithium chloride / tetrahydrofuran / 1 h / -35 - -25 °C
3.2: 4 h / -30 °C
With
copper(I) bromide dimethylsulfide complex; sodium ethanolate; pivaloyl chloride; triethylamine; lithium chloride;
In
tetrahydrofuran; ethanol; toluene;
