3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

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Chemical Name:3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid
CAS No.:1210857-22-9
Molecular Formula:C₂₇H₂₃FN₂O₃S
Molecular Weight:474.556
Hs Code.:

Synonyms:3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

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Chemical Property of 3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

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Technology Process of 3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

There total 4 articles about 3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1210857-20-7
3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid methyl ester

: 1210857-22-9
3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

Guidance literature:: 3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=2;

Reference yield:

: 1210859-07-6
Benzo[b]thiophen-2-yl-(2-fluoro-phenylamino)-acetic acid

: 1187932-57-5
C₁₁H₁₃NO₂

: 1210857-22-9
3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

Guidance literature:: Benzo[b]thiophen-2-yl-(2-fluoro-phenylamino)-acetic acid; C₁₁H₁₃NO₂; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 16h;

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2013.01.062

Reference yield:

: 98437-23-1
benzo[b]thiophene-2-boronic acid

: 1210857-22-9
3-{1-[2-Benzo[b]thiophen-2-yl-2-(2-fluoro-phenylamino)-acetyl]-pyrrolidin-2-yl}-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 3 h / Reflux

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dichloromethane / 16 h / 20 °C

2.2: 20 °C

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; acetonitrile; 1.1: |Mannich Aminomethylation;
DOI:10.1016/j.bmcl.2013.01.062