2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.0^2,6]hept-3-yl-phosphinic acid

Base Information

• Chemical Name: 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.0^2,6]hept-3-yl-phosphinic acid
• CAS No.: 137792-43-9
• Molecular Formula: C₈H₉ClN₂S*C₈H₁₃O₂P
• Molecular Weight: 372.856

Synonyms:2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.0^2,6]hept-3-yl-phosphinic acid

Chemical Property of 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.0^2,6]hept-3-yl-phosphinic acid

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Technology Process of 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.0^2,6]hept-3-yl-phosphinic acid

There total 5 articles about 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.0^2,6]hept-3-yl-phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

S-(4-chlorobenzyl)isothiourea hydrochloride (544-47-8) + Methyltricyclo<2.2.1.02,6>hept-3-ylphosphonic Acid (57322-29-9) → 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.02,6]hept-3-yl-phosphinic acid (137792-43-9)

Guidance literature:

With sodium hydroxide; In ethanol; at 95 ℃; for 0.166667h;

DOI:10.1021/jo00028a022

Reference yield:

4-Chloro-4-methyl-4-phosphoniatetracyclo<3.3.0.02,8.03,6>octane Chloride (57358-15-3) → 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.02,6]hept-3-yl-phosphinic acid (137792-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / H₂O / CHCl₃

2: aq. NaOH / 48 h / Heating

3: 85 percent / aq. NaOH / ethanol / 0.17 h / 95 °C

With sodium hydroxide; water; In ethanol; chloroform;

DOI:10.1021/jo00028a022

Reference yield:

trans-4-Methyl-4-phosphatetracyclo<3.3.0.02,8.03,6>octane 4-Oxide (768-26-3,57377-76-1,57377-77-2) → 2-(4-Chloro-benzyl)-isothiourea; compound with methyl-(1S,3R,4S)-tricyclo[2.2.1.02,6]hept-3-yl-phosphinic acid (137792-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 48 h / Heating

2: 85 percent / aq. NaOH / ethanol / 0.17 h / 95 °C

With sodium hydroxide; In ethanol;

DOI:10.1021/jo00028a022

upstream raw materials:

S-(4-chlorobenzyl)isothiourea hydrochloride

Methyltricyclo<2.2.1.0^2,6>hept-3-ylphosphonic Acid

4-Chloro-4-methyl-4-phosphoniatetracyclo<3.3.0.0^2,8.0^3,6>octane Chloride

trans-4-Methyl-4-phosphatetracyclo<3.3.0.0^2,8.0^3,6>octane 4-Oxide

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