3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

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Chemical Name:3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one
CAS No.:150966-37-3
Molecular Formula:C₃₂H₂₉N₃O₅S
Molecular Weight:567.665
Hs Code.:

Synonyms:3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

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Chemical Property of 3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

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Technology Process of 3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

There total 4 articles about 3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-((3aS,4R,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-4-ethoxymethyleneamino-isothiazole-5-carboxylic acid ethyl ester

: 150966-37-3
3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

Guidance literature:: With ammonia; In ethanol; at 25 ℃; for 24h; Yield given;
DOI:10.1021/jo00071a030

Reference yield:

: 56703-40-3
2-(2,3-O-Isopropylidene-5-O-trityl-β-D-ribofuranosyl)acetonitrile

: 150966-37-3
3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) isopentyl nitrite, NaH, 2.) glacial acetic acid / 1.) DME, 25 deg C, 2.) DME, 25 deg C, 15 h

2: 52 percent / Et₃N, ethyl 2-mercaptoacetate / 24 h / 25 °C

3: 16 h / 120 °C

4: NH₃ / ethanol / 24 h / 25 °C

With ammonia; sodium hydride; acetic acid; triethylamine; ethyl 2-sulfanylacetate; isopentyl nitrite; In ethanol;
DOI:10.1021/jo00071a030

Reference yield:

: 2-(2,3-O-Isopropylidene-5-O-trityl-D-ribofuranosyl)-2-(tosyloximino)acetonitrile

: 150966-37-3
3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / Et₃N, ethyl 2-mercaptoacetate / 24 h / 25 °C

2: 16 h / 120 °C

3: NH₃ / ethanol / 24 h / 25 °C

With ammonia; triethylamine; ethyl 2-sulfanylacetate; In ethanol;
DOI:10.1021/jo00071a030