3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

Base Information

Chemical Name:3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)
CAS No.:1190761-89-7
Molecular Formula:C₂₀H₁₈ClN₁₃O₄
Molecular Weight:539.901
Hs Code.:

Synonyms:3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

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Chemical Property of 3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

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Technology Process of 3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

There total 5 articles about 3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190761-99-9
C₁₂H₁₂ClN₃O₂

: 7008-85-7
5-diazoimidazole-4-carboxamide

: 1190761-89-7
3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 24h; Inert atmosphere; Darkness;
DOI:10.1021/jm401121k

Reference yield:

: 106-47-8
4-chloro-aniline

: 1190761-89-7
3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) chloride; acetic acid / 48 h / 140 °C

2: hydrazine hydrate / isopropyl alcohol / 48 h / 20 °C

3: hydrogenchloride; sodium nitrite / water; dichloromethane / 5 - 20 °C

4: toluene / 2 h / Reflux; Inert atmosphere

5: dimethyl sulfoxide / 24 h / 20 °C / Inert atmosphere; Darkness

With hydrogenchloride; hydrazine hydrate; acetic acid; copper(l) chloride; sodium nitrite; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene; 4: |Curtius Rearrangement;
DOI:10.1021/jm401121k

Reference yield:

: 1190761-96-6
3-[4-chloro(3-hydrazino-3-oxopropyl)anilino]propanohydrazide

: 1190761-89-7
3,3′-(2,2′-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide)

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / water; dichloromethane / 5 - 20 °C

2: toluene / 2 h / Reflux; Inert atmosphere

3: dimethyl sulfoxide / 24 h / 20 °C / Inert atmosphere; Darkness

With hydrogenchloride; sodium nitrite; In dichloromethane; water; dimethyl sulfoxide; toluene; 2: |Curtius Rearrangement;
DOI:10.1021/jm401121k