3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one
CAS No.:1312226-29-1
Molecular Formula:C₂₀H₁₇N₃O
Molecular Weight:315.374
Hs Code.:

Synonyms:3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

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Chemical Property of 3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

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Technology Process of 3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

There total 6 articles about 3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312226-27-9
C₂₀H₁₅N₃O₃

: 1312226-29-1
3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Guidance literature:: With 10% palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2011.04.008

Reference yield:

: C₁₂H₁₀N₂O₃

: 1312226-29-1
3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / methanol / 65 °C

2: 10% palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C

With piperidine; 10% palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2011.04.008

Reference yield:

: 61858-45-5
C₁₄H₁₄N₂O₄

: 1312226-29-1
3-[[3-(3-aminophenyl)-5-methyl-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / Reflux

2.1: trichlorophosphate / 0.25 h

2.2: 0.25 h / Reflux

2.3: 0.33 h / Reflux

3.1: piperidine / methanol / 65 °C

4.1: 10% palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C

With piperidine; 10% palladium on activated charcoal; hydrogen; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2011.04.008