2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole
• CAS No.: 91110-26-8
• Molecular Formula: C₂₉H₂₉N₃O₄
• Molecular Weight: 483.567
• Mol file: 91110-26-8.mol

Synonyms:2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole

Chemical Property of 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole

There total 6 articles about 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7α-hydrazinocarbonyl-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine (24482-20-0) + orthobenzoic acid trimethyl ester (707-07-3) → 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole (91110-26-8)

Guidance literature:

In various solvent(s); for 24h; Heating;

DOI:10.1021/jm00376a008

Reference yield: 66.0%

1-[(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-carbonyl]-2-benzoylhydrazine hydrochloride → 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole (91110-26-8)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

DOI:10.1002/jhet.1074

Reference yield:

7α-methoxycarbonyl-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine (16193-33-2) → 2-(6,14-endo-etheno-6,7,8,14-tetrahydrothebaine-7α-yl)-5-phenyl-1,3,4-oxadiazole (91110-26-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 2-ethoxy-ethanol

2: toluene / 1 h / Reflux

3: trichlorophosphate / 3 h / Reflux

With hydrazine hydrate; trichlorophosphate; In 2-ethoxy-ethanol; toluene;

DOI:10.1002/jhet.1074

upstream raw materials:

7α-hydrazinocarbonyl-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

orthobenzoic acid trimethyl ester

thebaine

7α-methoxycarbonyl-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine