H-Gly-NHNH-Z

Base Information

• Chemical Name: H-Gly-NHNH-Z
• CAS No.: 46742-14-7
• Molecular Formula: C₁₀H₁₃N₃O₃
• Molecular Weight: 223.232
• Mol file: 46742-14-7.mol

Synonyms:Carbazicacid, 3-glycyl-, benzyl ester (5CI); Hydrazinecarboxylic acid,2-(aminoacetyl)-, phenylmethyl ester (9CI)

Chemical Property of H-Gly-NHNH-Z

Chemical Property:

• PSA: 93.45000
• LogP: 1.38480

Purity/Quality:

99% ^*data from raw suppliers

Benzyl2-(2-aminoacetyl)hydrazinecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Gly-NHNH-Z

There total 5 articles about H-Gly-NHNH-Z which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DBC (3459-92-5) → glycine-(N'-benzyloxycarbonyl-hydrazide) (46742-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N₂H₄+H₂O / 110 °C

2: ethyl acetate

3: methanol; N₂H₄+H₂O

With methanol; hydrazine hydrate; ethyl acetate;

DOI:10.1021/ja01122a057

Reference yield:

N,N-phthaloyl-glycine-(N'-benzyloxycarbonyl-hydrazide) (111411-69-9) → glycine-(N'-benzyloxycarbonyl-hydrazide) (46742-14-7)

Guidance literature:

With methanol; hydrazine hydrate;

DOI:10.1021/ja01122a057

Reference yield:

N-benzyloxycarbonyl-hydrazine (5331-43-1) → glycine-(N'-benzyloxycarbonyl-hydrazide) (46742-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate

2: methanol; N₂H₄+H₂O

With methanol; hydrazine hydrate; ethyl acetate;

DOI:10.1021/ja01122a057

upstream raw materials:

2-thioxo-thiazolidin-5-one

N-benzyloxycarbonyl-hydrazine

N,N-phthaloyl-glycine-(N'-benzyloxycarbonyl-hydrazide)

BOC-glycine

Refernces

• 1、 Ondetti,Narayanan,von Saltza,Sheehan,Sabo,Bodanszky. "The synthesis of secretin. 3. The fragment-condensation approach.". . p. 4711 - 4715. Retrieved 2007/10/06.