methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

Base Information

Chemical Name:methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate
CAS No.:1372890-40-8
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

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Chemical Property of methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

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Technology Process of methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

There total 4 articles about methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1372890-39-5
methyl 2-{3-[(tert-butoxycarbonyl)(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

: 1372890-40-8
methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; at 20 ℃; for 24h;

Reference yield:

: 223671-15-6
7-bromo-1(2H)-isoquinolone

: 1372890-40-8
methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / dimethyl sulfoxide / 18 h / 70 °C / 760.05 Torr / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane; water / 24 h / 20 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 658082-39-4
methyl 1-oxo-2H-isoquinoline-7-carboxylate

: 1372890-40-8
methyl 2-{3-[(4-methoxyphenyl)amino]propyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; water / 24 h / 20 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;