Technology Process of ethyl 3-(4-bromophenyl)-2-(3,4-dihydro-2H-pyran-6-carbonyl)acrylate
There total 4 articles about ethyl 3-(4-bromophenyl)-2-(3,4-dihydro-2H-pyran-6-carbonyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
piperidine; acetic acid;
In
dichloromethane;
Molecular sieve;
DOI:10.1021/acs.joc.9b01083
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 - 20 °C
1.2: 0.5 h / -78 - 20 °C
2.1: sodium hydrogencarbonate / methanol / 0.5 h / 20 °C
2.2: 5 h / Reflux
3.1: ethylmagnesium bromide; di-n-propylamine / tetrahydrofuran; diethyl ether / 20 °C
4.1: piperidine; acetic acid / dichloromethane / 16 h / 20 °C / Molecular sieve
With
piperidine; ethylmagnesium bromide; tert.-butyl lithium; sodium hydrogencarbonate; di-n-propylamine; acetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; pentane;
4.1: |Knoevenagel Condensation;
DOI:10.1039/c4cc06501h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / methanol / 0.5 h / 20 °C
1.2: 5 h / Reflux
2.1: ethylmagnesium bromide; di-n-propylamine / tetrahydrofuran; diethyl ether / 20 °C
3.1: piperidine; acetic acid / dichloromethane / 16 h / 20 °C / Molecular sieve
With
piperidine; ethylmagnesium bromide; sodium hydrogencarbonate; di-n-propylamine; acetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
3.1: |Knoevenagel Condensation;
DOI:10.1039/c4cc06501h
