3-(dimethylamino)-2-phenoxypropanoic acid

Base Information

• Chemical Name: 3-(dimethylamino)-2-phenoxypropanoic acid
• CAS No.: 2132-43-6
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 2132-43-6.mol

Synonyms:3-(dimethylamino)-2-phenoxypropanoic acid

Chemical Property of 3-(dimethylamino)-2-phenoxypropanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-(dimethylamino)-2-phenoxypropanoic acid

There total 3 articles about 3-(dimethylamino)-2-phenoxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 3-(dimethylamino)-2-phenoxypropanoate (132291-69-1) → 3-(dimethylamino)-2-phenoxypropanoic acid (2132-43-6)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

ethyl 3-(benzyloxy)-2-phenoxypropanoate → 3-(dimethylamino)-2-phenoxypropanoic acid (2132-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol; water / 2 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With 20% palladium hydroxide-activated charcoal; water; hydrogen; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

→ 3-(dimethylamino)-2-phenoxypropanoic acid (2132-43-6)

Guidance literature:

Phenoxy-malonsaeure, Dimethylamin, Formaldehyd, W., Eg.;

upstream raw materials:

ethyl 3-(dimethylamino)-2-phenoxypropanoate

Refernces