(1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate

Base Information

Chemical Name:(1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate
CAS No.:1202448-15-4
Molecular Formula:C₂₅H₂₆ClFO₄
Molecular Weight:444.93
Hs Code.:

Synonyms:(1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate

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Chemical Property of (1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate

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Technology Process of (1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate

There total 1 articles about (1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1202447-89-9
(E)-tert-butyl 2-fluoro-3-oxo-5-phenylpent-4-enoate

: 91574-67-3,91574-68-4,20766-37-4
2-chlorobenzalacetone

: 1202448-04-1
(1S,6S,E)-tert-butyl 6-(2-chlorophenyl)-1-fluoro-4-oxo-2-styrylcyclohex-2-enecarboxylate

: 1202448-15-4
(1R,2S,6S,E)-tert-butyl 2-styryl-6-(2-chlorophenyl)-1-fluoro-2-hydroxy-4-oxocyclohexanecarboxylate

: (E)-tert-butyl 6-(2-chlorophenyl)-1-fluoro-4-oxo-2-styrylcyclohex-2-enecarboxylate

Guidance literature:: With (S)-3-(1H-indol-3-yl)-N₁-propylpropane-1,2-diamine; 4-nitro-benzoic acid; In chloroform; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/jo902081w