4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

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Chemical Name:4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone
CAS No.:1279126-56-5
Molecular Formula:C₂₁H₂₃N₃O₂
Molecular Weight:349.433
Hs Code.:

Synonyms:4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

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Chemical Property of 4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

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Technology Process of 4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

There total 7 articles about 4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1279126-54-3
4-[(4-methoxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

: 1279126-56-5
4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Guidance literature:: With boron tribromide; In hexane; dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1021/jm1013874

Reference yield:

: 955359-82-7
1,1-dimethylethyl (2R)-2-{[4-(4-methoxyphenylmethyl)-1-oxo-2(1H)-phthalazinyl]methyl}pyrrolidine-1-carboxylate

: 1279126-56-5
4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

2: formic acid / water / 95 °C

3: boron tribromide / hexane; dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With formic acid; boron tribromide; trifluoroacetic acid; In hexane; dichloromethane; water; 2: Eschweiler-Clarke reaction;
DOI:10.1021/jm1013874

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1279126-56-5
4-[(4-hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate / 2.5 h / 240 °C / Inert atmosphere

2: sodium hydroxide; hydrazinium sulfate / ethanol; water / 18 h / 95 °C

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 20 °C

4: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

5: formic acid / water / 95 °C

6: boron tribromide / hexane; dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With formic acid; di-tert-butyl-diazodicarboxylate; sodium acetate; boron tribromide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; hydrazinium sulfate; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; 3: Mitsunobu reaction / 5: Eschweiler-Clarke reaction;
DOI:10.1021/jm1013874