(6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

Base Information

Chemical Name:(6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone
CAS No.:1584112-52-6
Molecular Formula:C₂₇H₂₈F₃N₃O₃
Molecular Weight:499.533
Hs Code.:

Synonyms:(6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

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Chemical Property of (6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

Chemical Property:

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Technology Process of (6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

There total 4 articles about (6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584114-12-4
6-(3-(dimethylamino)-1-phenylpropoxy)nicotinic acid

: 178896-79-2
5-methoxy-6-(trifluoromethyl)indoline

: 1584112-52-6
(6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 49608-01-7
6-chloro-3-pyridinecarboxylic acid ethyl ester

: 1584112-52-6
(6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 0 °C

1.2: 20 °C

2.1: potassium hydroxide; water / ethanol / 1 h / Reflux

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With potassium tert-butylate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1584114-11-3
ethyl 6-(3-(dimethylamino)-1-phenylpropoxy)nicotinate

: 1584112-52-6
(6-(3-(dimethylamino)-1-phenylpropoxy)pyridin-3-yl)(5-methoxy-6-(trifluoromethyl)indolin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / ethanol / 1 h / Reflux

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;