4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide

Base Information

• Chemical Name: 4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide
• CAS No.: 101713-41-1
• Molecular Formula: BrH*C₁₆H₁₀BrCl₂NO
• Molecular Weight: 463.983
• Mol file: 101713-41-1.mol

Synonyms:4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide

Chemical Property of 4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide

There total 1 articles about 4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-Chloro-1-(2-chloro-phenyl)-3,4-dihydro-benzo[c]azepin-5-one; hydrobromide (101713-47-7) → 4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide (101713-41-1)

Guidance literature:

With bromine; In dichloromethane; for 0.5h;

DOI:10.1021/jo00362a007

Reference yield: 93.0%

4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide (101713-41-1) → 8-chloro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one (101713-42-2)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jo00362a007

Reference yield:

4-bromo-8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one hydrobromide (101713-41-1) → 8-chloro-1-(2-chlorophenyl)-4,5-dihydro-3-methoxy-3H-2-benzazepine (101713-34-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

2: 53 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / -78 °C

4: 20 percent / H₂ / Raney nickel / tetrahydrofuran / 1 h / 760 Torr / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; triethylamine; nickel; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00362a007

upstream raw materials:

8-Chloro-1-(2-chloro-phenyl)-3,4-dihydro-benzo[c]azepin-5-one; hydrobromide

Downstream raw materials:

8-chloro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

8-chloro-1-(2-chlorophenyl)-1,2-dihydro-5H-2-benzazepin-5-one

8-chloro-1-(2-chlorophenyl)-5H-2-benzazepin-5-ol

8-chloro-1-(2-chlorophenyl)-4,5-dihydro-3-methoxy-3H-2-benzazepine