3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Base Information

Chemical Name:3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine
CAS No.:1339035-99-2
Molecular Formula:C₃₂H₃₇FN₆O₂
Molecular Weight:556.683
Hs Code.:

Synonyms:3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Suppliers and Price of 3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

There total 4 articles about 3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 956-61-6
1-(4-tert-butylbenzyl)piperazine

: 1254703-70-2
C₁₇H₁₅FN₄O₃

: 1339035-99-2
3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 1254703-63-3
3-(1-(6-chloropyridazin-3-yl)-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propanoic acid

: 1339035-99-2
3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / Reflux

1.2: Acidic conditions

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1339035-99-2
3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-fluorophenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Alkaline conditions

2.1: triethylamine / methanol / Reflux

3.1: methanol / Reflux

3.2: Acidic conditions

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009