tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate
• CAS No.: 643746-87-6
• Molecular Formula: C₁₆H₂₂F₂N₂O₂
• Molecular Weight: 312.36
• Mol file: 643746-87-6.mol

Synonyms:tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate

Chemical Property of tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate

There total 3 articles about tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(5-{[(benzyloxy)carbonyl]amino}-2,4-difluorophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate (643746-86-5) → tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate (643746-87-6)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; ethyl acetate; at 20 ℃; for 72h; under 10343.2 Torr;

Reference yield: 94.0%

tert-butyl 4-(5-nitro-2,4-difluorophenyl)-3,6-dihydro-1(2H)-pyridine carboxylate (858681-97-7) → tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate (643746-87-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; water; for 16h; under 3102.97 Torr;

Reference yield:

→ tert-butyl 4-(5-amino-2,4-difluorophenyl)-1-piperidinecarboxylate (643746-87-6)

Guidance literature:

upstream raw materials:

tert-butyl 4-(5-{[(benzyloxy)carbonyl]amino}-2,4-difluorophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

tert-butyl 4-(5-nitro-2,4-difluorophenyl)-3,6-dihydro-1(2H)-pyridine carboxylate

Downstream raw materials:

tert-butyl 4-(2,4-difluoro-5-{[5-(2-methoxyphenyl)pentanoyl]amino}phenyl)-1-piperidinecarboxylate