1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

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Chemical Name:1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide
CAS No.:1400001-70-8
Molecular Formula:C₃₁H₄₆BrN₅O₅
Molecular Weight:648.641
Hs Code.:

Synonyms:1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

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Chemical Property of 1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

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Technology Process of 1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

There total 4 articles about 1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 111-26-2
hexan-1-amine

: 1400001-62-8
N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)proline

: 1400001-70-8
1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/hlca.201200136

Reference yield:

: 177747-22-7
methyl N-(2,2-dimethyl-2H-azirin-3-yl)-L-prolinate

: 1400001-70-8
1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 103 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

3: dichloromethane / 27 h / 0 - 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 22 h / 20 °C

5: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/hlca.201200136

Reference yield:

: 1400001-61-7
N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)proline methyl ester

: 1400001-70-8
1-[N-(4-bromobenzoyl)-2-methylalanyl]-N-{1-[2-(hexylcarbamoyl)pyrrolidin-2-yl]-2-methyl-1-oxopropan-2-yl}prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 22 h / 20 °C

2: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/hlca.201200136