2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

Base Information

Chemical Name:2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]
CAS No.:112905-89-2
Molecular Formula:C₂₃H₂₆N₂O
Molecular Weight:346.472
Hs Code.:

Synonyms:2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

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Chemical Property of 2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

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Technology Process of 2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

There total 4 articles about 2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 112905-98-3
1-<<1-<3-hydroxy-2(3H)-oxo-3-phenylindolyl>>methyl>cycloheptanecarbonitrile

: 112905-89-2
2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

Guidance literature:: With ammonia; hydrogen; nickel; In ethanol; at 50 ℃; for 2h; under 3040 - 3800 Torr;
DOI:10.1021/jm00085a001

Reference yield:

: 139018-14-7,1848-24-4
3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one

: 112905-89-2
2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

Guidance literature:: Multi-step reaction with 2 steps

1: 27 percent / t-BuOK / dimethylsulfoxide / 18 h / 130 °C

2: 49 percent / H₂, NH₃, Raney nickel / ethanol / 2 h / 50 °C / 3040 - 3800 Torr

With potassium tert-butylate; ammonia; hydrogen; nickel; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00085a001

Reference yield:

: 112905-99-4
1-(chloromethyl)cycloheptanecarbonitrile

: 112905-89-2
2',3',4',10'-Tetrahydro-10'-hydroxy-10'-phenylspiro [cycloheptane-1,3'-pyrimido(1,2-a)indole]

Guidance literature:: Multi-step reaction with 2 steps

1: 27 percent / t-BuOK / dimethylsulfoxide / 18 h / 130 °C

2: 49 percent / H₂, NH₃, Raney nickel / ethanol / 2 h / 50 °C / 3040 - 3800 Torr

With potassium tert-butylate; ammonia; hydrogen; nickel; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00085a001